Fig. 2
From: Drug and disease signature integration identifies synergistic combinations in glioblastoma
Clustering of TCGA samples and GBM PDX samples using the L1000 gene set reflects cancer types. a PCA plot, b Hierarchical Clustering, and c t-distributed stochastic neighbor embedding (tSNE) plot of 4515 RNA-Seq TCGA tumor samples labeled based on their cancer type by using the expression of only 978 genes. d Heatmap of the Spearman correlation of 41 PDX GBM samples from Mayo Clinic and 4515 tumor samples downloaded from TCGA. Cancer types: BRCA: breast invasive carcinoma, COAD: colon adenocarcinoma, GBM: glioblastoma, HNSC: head-neck squamous cell carcinoma, KIRC: kidney renal clear cell carcinoma, LUAD: lung adenocarcinoma, LUSC: lung squamous cell carcinoma, READ: rectum adenocarcinoma, UCEC: uterine corpus endometrial carcinoma, OV: ovarian cancer
