Fig. 3
From: Drug and disease signature integration identifies synergistic combinations in glioblastoma
Transcriptional consensus signatures can identify common transcriptional responses to compounds. a Histogram of the number of genes in the TCS per compound. Most of the compounds tested have a low number of genes in their TCS. b The number of genes that each compound has in its TCS is correlated with the Transcription activity score, a metric for the consistency in a compound’s transcriptional response. PCC: Pearson correlation coefficient. c Specificity and concordance of L1000 compounds compared to the JQ1 TCS. Only a few compounds overlap and have a concordant transcriptional response with the JQ1 TCS. d The JQ1 Transcriptional response signature. The top two (e, f) and the bottom two (g, h) compounds with the highest specificity to the JQ1 TCS. i The top 10 compounds with the highest concordance to the JQ1 TCS are BET inhibitors
