Fig. 1
From: Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
HMGNs localize to tissue specific chromatin regulatory sites. a Clustering map showing preferential localization of HMGN1 and HMGN2 with epigenetic marks of active chromatin in ESCs. *: data from our experiments. b Coincident HMGN occupancy at annotated promoters, but not at non-promoter regions in MEFs, rBs, and ESCs. c High HMGN1 occupancy at cell-specific expressed genes. d, e HMGN occupancy correlates directly with cell-specific gene expression levels. Genes are sorted into 9 tiers based on expression value (d). HMGN1 occupancy at the promoter of each group sorted by expression levels (e). f Cell-type-specific co-localization of HMGN1 with histone modifications marking cell-type-specific chromatin regulatory regions. g Normalized average intensity and Venn diagrams showing preferential localization of HMGN1 and HMGN2 at cell specific super-enhancers. All data from at least two biological replicates for each HMGN variant
