Fig. 4
Trodusquemine modifies the biophysical properties of Aβ42 oligomers. a The binding of 15 µM ANS to 5 µM Aβ42 oligomers after incubation for 1 h at 20 °C in the absence (black) and presence of 10:1, 3:1, 1:1, 1:3 and 1:10 ratios (light blue to purple) of Aβ42-to-trodusquemine. Spectra were normalized to the intensity of ANS fluorescence for Aβ42 oligomers. Mean ± s.e.m. of duplicate samples. Data shown are representative of three-independent experiments that yielded similar results. b Static light scattering measurements of 5 µM Aβ42 oligomers after incubation for 1 h at 20 °C in the absence or presence of 10:1, 3:1, 1:1, 1:3 and 1:10 ratios of Aβ42-to-trodusquemine. Mean ± s.e.m. of three replicates. *P < 0.05, **P < 0.01 by Student’s t-test
