Fig. 1
From: Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set
IMEx mutations data set overview. a Number of annotations by effect type; b Increase of reported protein interactions involving wild type and mutated proteins over time. Bars represent total number of PPIs reported each year (wild type proteins in gold, mutated proteins in blue). Lines represent the cumulative sum of PPIs with mutated proteins, with the solid line representing the actual cumulative trend and the dashed line showing a projection for the last 3 years; c Distribution of the number of mutation annotations by interaction detection method; d Distribution of the number of mutation annotations captured per publication. The number of annotations per publication is shown on a log scale; e Number of mutation annotations per database of origin; f Internal consistency of repeatedly reported mutations. ‘Conflict’ cases are those in which the effects reported are antagonistic (e.g. ‘disrupting’ vs ‘increasing’). ‘Mild conflict’ cases are those in which the mutation is sometimes reported as having some effect vs others in which there is no detectable effect
