Fig. 4
From: Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set
Computational annotations and the IMEx mutations data set. a Interaction interface disruption as predicted with FoldX, by mutation effect type. Indicated p-values calculated with Wilcoxon test (decreasing vs no effect W = 25,100; disrupting vs no effect W = 24,411); b Proportion of highly disruptive variants by mutation effect type; c Proportion of low tolerance residue positions according to the SIFT, by mutation effect type; d ExAC-extracted allele frequencies for mutations represented in the IMEx data set, by mutation effect type; e Low frequency variants, by mutation effect type. Indicated p-values calculated with Wilcoxon test (decreasing vs no effect W = 1841.5; disrupting vs no effect W = 2389.5; increasing vs no effect W = 645); f Proportion of deleterious substitutions according to Polyphen2, by mutation effect type; g Number of mutation annotations located in binding interfaces (curated and predicted), by effect; h Normalized frequencies of mutation annotations reporting effects over interactions or not and their localization in binding interfaces. p-values indicated in panels b, c, d and f were calculated with Fisher exact test. Source data are provided as a Source Data file
