Fig. 2
From: Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
Muc5b overexpression in SFTPC-Muc5bTg mice is associated with impaired mucociliary transport. a Representative μOCT images of excised SFTPC-Muc5bTg mice trachea in comparison to trachea of wild type (+) littermate controls. b–e Quantitative metrics from image analysis reveal increased mucus layer depth b without significant alteration of periciliary layer (PCL) depth c in Tg mice compared to + controls. Functional analysis demonstrated reduced ciliary beat frequency d and diminished mucociliary transport rates e in Muc5b-overexpressing mice. Data in b–e are means ± sem and were analyzed by Mann–Whitney test
