Fig. 3
From: Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
ZIKV genome targeting for mir-202–5p restricts virus ability to infect cells of the seminiferous tubules. Adult AG129 mice were infected ip with 106 pfu of 2×scr, various miRNA-targeted viruses, or mock-inoculated and killed at 3 dpi a–c or 12 dpi d–i. Representative images of ZIKV antigen distribution in the testes of mice that were mock-inoculated or infected with indicated viruses are shown on the indicated dpi (2–6 mice per group). ZIKV antigen in a whole testis are shown in the top panel. Red boxes indicate the areas which are presented at higher magnification images on the bottom of each panel. Testicular structural elements are indicated in a–c. The cellular elements of seminiferous tubules are indicated in d. Labeling used within panels is indicated at the bottom of the figure. Scale bars: 10 µm
