Fig. 5
From: The gut microbiome is required for full protection against acute arsenic toxicity in mouse models
Specific microbiome OTUs are risk factors for survival. The presence/absence of the 100 most abundant OTUs in the dataset were fit to univariate Cox proportional hazards (CPH) models. a, b Controlling for false discovery rate (<0.1), significant beta coefficients (with standard error) for microbiome members at day 0 (a, left panel) and day 7 (b, left panel) are shown along with the group-wise prevalence of each OTU displayed as heat maps (a, b, right panels). Donor groups in heat maps (A–E) are ordered by median survival during arsenic exposure (shortest survival on left, longest survival on right). Significant OTUs found on both sampling days (0 and 7) are shown with black bars and significant OTUs found to be unique on one day or the other are shown in open bars. CPH models correlate explanatory variables with a relative hazard function, therefore, a negative beta coefficient indicates a protective association, while positive coefficients are associated with increased hazard. OTUs were classified to the lowest taxonomic level at a 95% confidence. Taxonomic levels above genera are indicated in parentheses (F family, O order, P phylum)
