Fig. 5
Generalizable crystallization platform for diverse HIV-1 envelope and drug complexes. a B41 SOSIP.664 Env trimeric structure in surface representation shows gp120 in black and gp41 in gray; the residues that differ between the B41 SOSIP.664 and BG505 SOSIP.664 Env trimers are colored as red. b B41 SOSIP.664 Env trimeric structure is shown in the context of P63 lattice. c Structures of BMS-386150 in complex with the BG505 (top) or B41 (bottom) SOSIP.664 Env trimers. Residues interacting with BMS-386150 that are different between B41 and BG505 are highlighted in black box. d The backbone conformational differences in the structures of BMS-386150 complexed with BG505 (purple) or B41 (yellow) are shown as ribbon diagram (top), the same region in the apo-form BG505 and B41 are also shown (bottom)
