Fig. 1
From: Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
Crystal structure of ACER3. a Overall view of ACER3 crystal structure at 2.7 Å from within the membrane plane. The zinc and calcium ions are represented as spheres with a van der Waals radius of 0.88 and 1.14, respectively. Side chains of residues in close proximity to both ions are shown as sticks. b Close-up view of the N-terminus (colored from blue to red) and intracellular loop 3 (ICL3, colored in light blue) domains highlighting the disulfide bond formed by C21 and C196 (sticks). c Cartoon representation of the N-terminus domain colored as in (b) (left) revealing a spiral-like motif (right)
