Fig. 4
From: Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
Cu-SAA/KR using trans-cyclic phosphates. Reaction conditions: Cu-SAA and Cu-KR see Table 1, entry 9; a LiAlH4 (2.2 eq), Et2O, rt; b HCO2H (2.05 eq), DIAD (2.0 eq), PPh3 (2.0 eq), Toluene 0 °C; c NEt3 (0.05 eq), MeOH, rt; d (EtO)2P(O)Cl (2.0 eq), NEt (2.0 eq), DMAP (0.33 eq), CH2Cl2, rt. Selectivity factor S calculated using S = ln[1 − c(1 + ee)]/ln[1 − c(1 − ee)]
