Fig. 7
From: PRMT5 is essential for B cell development and germinal center dynamics
Prmt5 is required for B cell development. a BM lymphocytes and splenic B cells in MB1-cre (Ctrl) or Prmt5F/F MB1-cre (F/F) mice. Representative flow cytometry plots and bar plots of mean + s.d. absolute lymphocyte counts for n mice from four experiments. b Representative flow cytometry plots gating for Hardy fractions A to E in BM from 3–4-months-old MB1-cre (Ctrl) and Prmt5F/F MB1-cre (F/F) mice. Means + s.d. of absolute cell numbers for each fraction from n of mice from four independent experiments are plotted. c As in b, for MB1-cre B1-8 (ki+/+) and Prmt5F/F MB1-cre B1-8 (ki F/F) mice, from three experiments. d As in b, for MB1-cre Trp53−/− (pko+/+) and Prmt5F/F MB1-cre Trp53−/− (pko F/F) mice, from three experiments. e Proportion of large Pre-B cells in fractions C+C′ estimated by the pre-BCR expression in individual (symbols) MB1-cre Trp53−/− (Ctrl) and Prmt5F/F MB1-cre Trp53−/− (F/F) mice. p-Values throughout are from an unpaired, two-tailed Student's t test
