Table 2 Survival analysis for IPs with top 10% parents and siblings
From: Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait
UPDB | LINKS | |||||
|---|---|---|---|---|---|---|
N (mean) | HR (95% CI) | p-Value | N (mean) | HR (95% CI) | p-Value | |
Top 10% parents (F1) | ||||||
0 (ref) | 6640 (0.65) | 7861 (0.78) | ||||
1 | 3167 (0.31) | 0.88 (0.83–0.92) | 2.94*10−7 | 2096 (0.20) | 0.82 (0.78–0.86) | 1.27*10−13 |
2 | 439 (0.4) | 0.73 (0.65–0.83) | 4.38*10−7 | 184 (0.2) | 0.69 (0.58–0.82) | 1.91*10−5 |
Top 10% sibs (F2) | ||||||
0 (ref) | 6720 (0.66) | 8644 (0.85) | ||||
1 | 2495 (0.24) | 0.82 (0.76–0.90) | 6.85*10−6 | 1256 (0.13) | 0.82 (0.73–0.93) | 1.38*10−3 |
2+ | 1031 (0.10) | 0.74 (0.66–0.82) | 4.15*10−8 | 214 (0.2) | 0.75 (0.58–0.96) | 2.30*10−2 |
LDS (F2) | ||||||
0—non-religious (ref) | 2753 (0.27) | |||||
1—baptized | 512 (0.05) | 0.73 (0.65–0.81) | 1.49*10−8 | NA | NA | NA |
2—baptized + endowment | 6736 (0.66) | 0.80 (0.76–0.85) | 2.33*10−15 | NA | NA | NA |
3—missing | 245 (0.02) | 0.85 (0.73–0.99) | 4.24*10−2 | NA | NA | NA |
Sibship size (F2) | 10,246 (6.28) | 1.01 (1.00–1.02) | 2.23*10−2 | 10,114 (6.34) | 1.01 (1.00–1.02) | 9.02*10−2 |
Birth cohort, years (F2) | 10,246 (1868) | 0.99 (>0.99 to <1.00) | 2.66*10−09 | 10,114 (1835) | 0.99 (>0.99 to <1.00) | <1.00*10−15 |
Sex (F2) | ||||||
Man (ref) | 5053 (0.49) | 4776 (0.48) | ||||
Women | 5193 (0.51) | 0.71 (0.67–0.76) | <1.00*10−15 | 5338 (0.52) | 1.01 (0.96–1.06) | 7.53*10−1 |
SES—OCC_1950 (F2) | ||||||
0—High (ref) | 315 (0.03) | 67 (0.01) | ||||
1 | 1482 (0.14) | 1.16 (1.01–1.34) | 3.95*10−2 | 645 (0.06) | 0.88 (0.68–1.14) | 3.42*10−1 |
2 | 400 (0.04) | 1.19 (1.00–1.40) | 4.95*10−2 | 536 (0.05) | 0.97 (0.75–1.27) | 8.42*10−1 |
3 | 352 (0.03) | 1.24 (1.05–1.48) | 1.38*10−2 | 62 (0.01) | 0.76 (0.53–1.10) | 1.45*10−1 |
4 | 187 (0.02) | 1.14 (0.93–1.40) | 2.09*10−1 | 71 (0.01) | 0.99 (0.70–1.40) | 9.41*10−1 |
5 | 891 (0.09) | 1.31 (1.13–1.52) | 4.22*10−4 | 733 (0.07) | 0.80 (0.62–1.04) | 9.19*10−2 |
6 | 668 (0.07) | 1.34 (1.15–1.56) | 2.13*10−4 | 311 (0.03) | 0.86 (0.65–1.13) | 2.71*10−1 |
7 | 522 (0.05) | 1.27 (1.08–1.50) | 4.14*10−3 | 759 (0.08) | 0.84 (0.65–1.10) | 2.01*10−1 |
8 | 168 (0.02) | 1.21 (0.97–1.50) | 8.91*10−2 | 574 (0.06) | 0.85 (0.65–1.11) | 2.35*10−1 |
9—Low | 562 (0.05) | 1.48 (1.26–1.73) | 1.70*10−6 | 3656 (0.36) | 0.83 (0.65–1.07) | 1.56*10−1 |
999—missing | 4699 (0.46) | 1.61 (1.40–1.84) | 9.54*10−12 | 2700 (0.26) | 0.93 (0.72–1.20) | 5.95*10−1 |
Log likelihood | −60,719 | −72,239 | ||||
