Table 3 Frailty survival analysis for children of IP’s with top 10% IPs and aunts and uncles
From: Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait
UPDB | LINKS | |||||
|---|---|---|---|---|---|---|
N (mean) | HR (95% CI) | p-Value | N (mean) | HR (95% CI) | p-Value | |
Top 10% IP (F2) | ||||||
0 non-LL (ref.) | 48,619 (0.80) | 53,378 (0.85) | ||||
1 LL | 12,179 (0.20) | 0.86 (0.84–0.89) | <1.00*10−15 | 9096 (0.15) | 0.85 (0.82–0.88) | <1.00*10−15 |
Top 10% aunts and uncles (F2) | ||||||
0 (ref.) | 39,474 (0.65) | 53,228 (0.85) | ||||
1 | 15,134 (0.25) | 0.96 (0.93–0.99) | 3.19*10−3 | 7817 (0.12) | 0.96 (0.92–0.99) | 1.90*10−2 |
2+ | 6190 (0.10) | 0.92 (0.88–0.96) | 4.33*10−5 | 1429 (0.3) | 0.84 (0.78–0.92) | 5.47*10−5 |
Sibshipsize (F3) | 60,798 (8.89) | 1.02 (1.01–1.02) | <1.00*10−15 | 62,474 (8.52) | 1.00 (>0.99 to <1.00) | 7.87*10−1 |
Birth year (F3) | 60,798 (1892) | 0.99 (>0.99 to <1.00) | <1.00*10−15 | 62,474 (1867) | 0.99 (>0.99 to <1.00) | 2.37*10−11 |
Sex (F3) | ||||||
Man (ref.) | 31,258 (0.51) | 32,136 (0.52) | ||||
Women | 29,540 (0.49) | 0.62 (0.60–0.63) | <1.00*10−15 | 30,338 (0.48) | 0.64 (0.63–0.66) | <1.00*10−15 |
Famid intercept (variance) | 60,798 (1.00) | 0.34 (0.11) | 62,474 (1.00) | 0.34 (0.11) | ||
BIC | 60,798 (1.00) | −23,756.54 | 62,474 (1.00) | −21,477.23 | ||
