Fig. 4 | Nature Communications

Fig. 4

From: Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

Fig. 4

Biochemical activity of SQLE inhibitors and their inactive analogs. a Structures of inactive analogs, NB-598.ia and Cmpd-4′′.ia. b NB-598 inhibits baculosome-derived SQLE with an IC50 of 63 nM, while the structural analog NB-598.ia has an IC50 of >100 μM (left panel) and Cmpd-4′′ inhibits baculosome-derived SQLE with an IC50 of 69 nM, while the structural analog Cmpd-4′′.ia has an IC50 of >100 μM (right panel). Points and error bars are the mean and standard deviation of triplicate experiments

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