Fig. 6
From: Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
Mechanism of action of SQLE inhibitors. a Time-dependent inhibition potency of NB-598 and Cmpd-4′′. The IC50 of NB-598 decreases from 120 nM to 30 nM and that of Cmpd-4′′ decreases from 800 to 69 nM upon increasing incubation time. b Mechanism-of-action study of NB-598 and Cmpd-4′′. NB-598 study was performed with fixed concentrations of inhibitor at 0, 10, and 40 nM indicating non-competitive inhibition with respect to squalene substrate. Cmpd-4′′ study was performed with fixed concentrations of inhibitor at 0, 30, 60, and 180 nM indicating non-competitive inhibition with respect to squalene substrate. Points and error bars are the mean and standard deviation of triplicate experiments
