Fig. 7
From: Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
FAD stabilization and implications for catalysis. FAD stabilization by Y335 water–bridged interaction. Hydrogen bonds to flavin N5 position to water and its network to Y335, I162, and E165 are illustrated by dashed lines with water shown as a red sphere. FAD (from SQLE•FAD•Cmpd-4′′ complex) and docked, superposed squalene (in cyan) are in stick representation with atom positions 2 and 3 shown as sites of stereo- and regio-specific epoxidation
