Table 1 Kinetic parameters for the SQLE reaction in different experimental models
From: Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
FAD KM (µM) | Squalene KM (µM) | kcat (min−1) | kcat/KM (M−1 min−1) | |
|---|---|---|---|---|
SQLE (118–574) | 5.2 ± 0.5 | 1.9 ± 0.4 | 2.09 ± 0.12 | 1.10 ± 0.9 × 106 |
SQLE baculosome | 8.1 ± 0.6 | 3.3 ± 0.7 | 1.40 ± 0.3 | 4.25 ± 0.8 × 105 |
HLMs | 9.6 ± 0.5 | 2.9 ± 0.2 | 0.21 ± 0.02 | 1.38 ± 0.4 × 104 |
