Fig. 5

Gastric cancer subtyping by tumor tissues or tumor nearby tissues. a The consensus clustering analysis of gastric cancer samples (n = 58) based on 582 outlier proteins in tumor tissues. b Heatmap display of three GCA subtypes clustered by tumor tissues (T1–T3) and molecular functions of these subtypes. c Survival analysis of gastric cancer patients in the three subtypes (T1–T3). d The consensus clustering analysis of gastric cancer samples (n = 58) based on 377 outlier proteins in tumor nearby tissues. e Heatmap display of four GCA subtypes clustered by tumor nearby tissues (P1–P4) and molecular functions of these subtypes. f Survival analysis of gastric cancer patients in the four subtypes (P1–P4). g Heatmap display of stomach and intestine enriched proteins in the proximal and distal regions respectively and their distributions in the N, TNT, and T samples. The I/C-enriched type samples were indicated by red arrows. h The relative abundances of the stomach and intestine enriched proteins in N, TNT, and T, separated by the distal and proximal sections (center line: median, bounds of box: 25th and 75th percentiles, and whiskers: from Q1 − 1.5*IQR to Q3 + 1.5*IQR). i Bar chart displaying the number of I/C enriched type and non-I/C enriched type samples in the distal and proximal sections (left panel) and three Lauren subtypes (diffuse, intestinal and mixed; right panel)