Fig. 5
Clonality of the tumor vasculature. a Schematic diagram of the Cdh5-CreER Rainbow lineage tracing model employed with B16-F0 melanoma cells injected at day 0 (D0), with mice receiving tamoxifen (Tam) 3-days post tumor inoculation (n = 5). b At day 5 multi-individual colored clones could be observed that were presumed to be EVP. By day 10 entire arterial (DLL4) and venous (endomucin-higher magnification) vessels were composed of multi colors demonstrating polyclonality. Scale bar represents 50–150 μm. EVP endovascular progenitors
