Fig. 1
From: Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions
Model for MPER accessibility within native Env complexes based on Cryo-EM reconstructions15. Top: Contours derived from detergent-solubilized Env trimers, without (left) or with 10E8 bound (right), have been docked into a viral lipid bilayer. A putative transition between these two states would result in exposure of the MPER helix in native Env (green). Bottom: cartoons to designate in the previous models the different trimer components, and positions of the neutralizing epitopes for bnAbs used in this study PGT145 (V1/V2), VRC01 and b12 (CD4bs); and 10E8/4E10 (MPER)
