Fig. 1
From: Promotion of homology-directed DNA repair by polyamines
Protective role of polyamines in the DNA damage response in hair follicles. a The morphology of hair follicle and hair cycle. Hair cycle consists of three stages: hair growth (anagen), regression (catagen) and resting (telogen). The matrix cells (Mx) residing in the hair bulb actively proliferate during anagen to support the continuous elongation of hair shafts and to generate the internal structures of hair follicles. b Histology of murine hair follicles upon treatment with DFMO, IR, or both. Scale bar, 75 μm. c The number of matrix cells (Mx) after treatment with DFMO, IR, or both. (n = 26 hair follicles) d Cell proliferation as measured by pulse BrdU labeling. Representative images and percentages of BrdU positive matrix cells were shown. (n = 13 hair follicles). Scale bar, 25 μm. ****P < 0.0001; NS, not significant (P > 0.05). Data are the mean ± s.e.m. from three independent experiments. Statistics was performed by one-way ANOVA with Tukey’s post hoc test. Source data are provided as a Source Data file
