Fig. 5 | Nature Communications

Fig. 5

From: RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

Fig. 5

HSPA1A protects against DMM-induced cartilage destruction. a, b Representative images of HSPA1A immunostaining in cartilage (a) and Safranin-O staining in joint sections (b) of mice IA injected with Ad-C or Ad-HSPA1A (n = 5 mice per group) once a week for 3 weeks. c, d Representative Safranin-O staining images (c) and scoring of OARSI grade, osteophyte maturity, and subchondral bone plate thickness (d) in sham (n = 8 mice per group)- or DMM (n = 17 mice for Ad-C and 15 mice for Ad-HSPA1A)-operated mice subjected to IA injection of Ad-C as a control or Ad-HSPA1A to overexpress HSP70 in the joint tissues. Means ± 95% CI with Mann–Whitney U test for OARSI grade and osteophyte maturity. Means ± s.e.m. with two-tailed t-test for SBP thickness. SBP subchondral bone plate. Scale bar: 50 μm

Back to article page