Fig. 7 | Nature Communications

Fig. 7

From: RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

Fig. 7

Knockdown of HSPA1A abrogates the inhibition of OA pathogenesis seen in Zfp36l1+/− mice. Sham- or DMM-operated WT and Zfp36l1+/− mice were IA injected with Ad-shC or Ad-shHSPA1A (n = 7 mice per group) and sacrificed at 8 weeks after the operation. a Representative images of Safranin-O staining and immunostaining of HSP70. b Quantitation of OA parameters (OARSI grade, osteophyte maturity, and subchondral bone plate thickness). Means ± 95% CI with Mann–Whitney U test for OARSI grade and osteophyte maturity. Means ± s.e.m. with two-tailed t-test for SBP thickness. Scale bar: 50 μm

Back to article page