Fig. 4
From: AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
AXL inhibitor sensitized AXL-high EGFR-mutant NSCLC cells to osimertinib. a PC-9, PC-9GXR, HCC4011, and HCC827 cells were incubated with osimertinib in the presence or absence of AXL inhibitor NPS1034 (1 μmol/L) for 72 h and the cell viability was determined using MTT assays. Data are representative of three independent experiments that produced similar results. b, c The indicated cells were incubated with osimertinib (100 nmol/L) with or without NPS1034 (1 μmol/L) for 1 h (b) and 72 h (c). The cells were lysed and the indicated proteins were detected by western blotting
