Fig. 6
Regional association (LocusZoom) plots for SNPs in the five genomic regions showing novel genome-wide significant associations to pigmentation traits. Chromosomal location and trait are specified in the title of each panel. In each region, index SNPs (Table 1) are highlighted with a purple diamond. Colors for other SNPs represent the strength of LD between that SNP and the index SNP (in the 1000 Genomes AMR data). Local recombination rate in the AMR data is shown as a continuous blue line (scale on the right y-axis). Genes in each region, their intron–exon structure, direction of transcription and genomic coordinates (in Mb, using the NCBI human genome sequence, Build 37, as reference) are shown in the middle of each panel. At the bottom is shown a pairwise LD heatmap across all SNPs in a region (using r2, ranging from red indicating r2 = 1 to white indicating r2 = 0)
