Fig. 7
From: Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
The subcellular distribution of β-catenin in Apc1332T adenoma cells is not sensitive to Bcl9 loss. IF of adenoma (ad) from (a) Apc1332T, (b) Apc1332T Bcl9/B9l DKO or ApcMin small intestines, and adjacent normal epithelia (ne), fixed and stained as in Fig. 5; scale bars, 50 μm. The nucleocytoplasmic β-catenin levels are barely elevated in Apc1332T adenomas (compared to ApcMin adenoma, red fluorescence in c) and their cell surface β-catenin is high (yellow fluorescence in a, b) regardless of Bcl9
