Fig. 1

Genomic binding of GR and E2A overlaps in mouse liver. a Bioinformatic motif analyses of the hepatic GR cistrome detect enriched transcription factor consensus sites in GR ChIP sequences. b Area-proportional Venn diagram depicting the overlap between the GR and E2A liver cistromes. Numbers of called peaks in at least one sample are shown (n = 2 biol. replicates). c Analogous motif analyses of the hepatic E2A ChIP sequences. d Functional annotation of shared GR-E2A target genes by GO analysis, assigning common ChIP peaks to the nearest coding gene. e Representative ChIP-Seq tracks displaying co-occupancy of GR and E2A at metabolic promoters and enhancers. Y-axes show normalized read counts