Fig. 6 | Nature Communications

Fig. 6

From: Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback

Fig. 6

WNT11 reduces the interbud distance during kidney branching morphogenesis. a–c Representative images of the epithelium from approximately equally sized a wild type (E14), b Wnt11+/− (E13.5), and c Wnt11−/− (E13.5) embryonic kidneys, as obtained by OPT. d Skeletonised renal epithelium (in grey) with epithelial tips marked in magenta and branching points in blue. e Area per ureteric bud versus kidney volume in wild type and mutant kidneys. f Median tip to tip distance versus kidney volume in wild type and mutant kidneys. g, h Distribution of tip to tip distances in g small (bin 1) and h large (bin 2) wild type and mutant kidneys. Detailed definition of quantitative metrics is available in the Supplementary Methods

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