Fig. 4
From: Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
Attenuation in linear relationship between polygenic scores (PS) and complex traits in the UK Biobank sample at varying degrees of statistical adjustment. N sibs refers to number of siblings. For each PS, the relationship with four traits was estimated using an unadjusted model (plotted in circle) and this estimate and its corresponding 95% confidence intervals were rescaled to a value of 1. Error bars represent 95% confidence intervals for the rescaled estimate. Adjustment was then performed for genotyping array only (triangles), genotyping array, 40 principal components (PCs) and study participation centre (cross) and 40 PCs, study participation centre and non-linear regression terms for North and East axes of birth location (square). A value of 0.5 on the y-axis would mean that 50% of the unadjusted effect estimate remained after adjustment. Lines are drawn at x = 1 (red) and y = 0 (black) for reference
