Fig. 5 | Nature Communications

Fig. 5

From: Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Fig. 5

AP-1 binding is context-dependent and affected by the availability of binding partners. a Heatmap of the change in binding of AP-1 monomers after 1-h Kdo2 lipid A (KLA) treatment quantified as the Log2 ratio of KLA binding to Vehicle binding. b Heatmap showing the transcription factor binding analysis (TBA) assigned significance of DNA motifs that had a 10e4 absolute likelihood ratio between the KLA and Vehicle value for each monomer. c Pearson correlation of individual motif scores and TBA predictions with the change in binding after 1 h KLA treatment. d–f TBA predicted change in ATF3, Jun, and JunD binding after KLA-1 h treatment versus actual change in binding. PCC indicates the Pearson correlation coefficient of TBA predictions to the log2 fold change in binding of each monomer after 1 h KLA treatment

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