Fig. 1

The accessible chromatin landscapes of human pre-implantation embryos. a Schematic representation of LiCAT-seq for simultaneous profiling of chromatin accessibility and transcriptome with ultra-low-input of cells. b Number of accessible regions detected at the indicated stages of embryo development. c Genomic distribution of chromatin accessibility peaks detected at the indicated stages. d Genome browser view of a representative region showing the chromatin accessibility and gene expression signals at each developmental stage. e Scatterplot of gene density (x axis) versus normalized read density (y axis) at each developmental stage. f Principal component plots of normalized chromatin accessibility and gene expression signals