Fig. 2
From: An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
Decomposition of gene expression and chromatin accessibility dynamics during embryonic genome activation. a Fuzzy clustering analysis of EGA gene expression signals for the indicated stages. The individual gray lines represent the expression level of individual genes, and the orange line represents the value for the cluster center. b Mean standardized chromatin accessibility of promoter peaks (light green) and distal peaks (dark green) for EGA genes in each cluster in a. Example genes for each cluster are listed in the right panel. c, d The dynamics of gene expression c and chromatin accessibility d for representative genes in each cluster. Source data used in this figure are provided as Supplementary Data 2. The error bars shown in this figure represent the mean ± standard deviation (SD) of two replicates
