Fig. 4

Chromatin accessibility and expression dynamics of retrotransposons during human pre-implantation development. a, b Heat maps showing chromatin accessibility a and expression b levels of retrotransposons at the indicated development stages. c, d Chromatin accessibility c and RNA d read enrichment around MLT2A1 elements at the indicated stages. e Enrichment of the indicated transcription factor motifs found within MLT2A1 elements that become accessible at the 4-cell stage. f Proportion of MLT2A1 elements that are bound by DUX4 within all MLT2A1 elements that become accessible at the 4-cell stage. g RNA read enrichment around HERVL elements at the indicated stages. h Genome browser views showing DUX4 binding, chromatin accessibility, and gene expression signal around a HERVL element flanked by MLT2A1. Source data used in this figure are provided as Supplementary Data 4