Fig. 5 | Nature Communications

Fig. 5

From: Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

Fig. 5

DNA damage, repair, gene expression, and epigenomic markers for Per1. Per1 is significantly upregulated after cisplatin treatment across all four organs. Damage-seq and XR-seq data are shown for both strands. Pt-d(GpG) damage (Damage-seq) and repair (XR-seq) distribution on the TS and NTS are shown with − and +, respectively. Epigenetic data from ChIP-seq of H3K4me3 and H3K27me3, as well as DNase-seq, are plotted at the bottom of each organ section. We show that the transcriptional and epigenomic profiles of Per1 and neighboring region across all four organs recapitulate the differences in DNA damage and repair between the TS and NTS

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