Fig. 8
From: The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
Activating O-GlcNAcylation promotes Treg cell suppressive function. a–c MFI of protein O-GlcNAcylation (a), FOXP3 (b, c) in mouse CD4+FOXP3+ Treg cells treated with TMG, H2O treatment was used as a control (n = 5). d, e mRNA levels of Socs1 (d) and Socs3 (e) in mouse Treg cells treated with TMG, H2O treatment was used as a control (n = 3). f Gene expression in iTreg cells treated with TMG, H2O treatment was used as a control (n = 2). g, h MFI of protein O-GlcNAcylation (g) and FOXP3 (h) in human tTreg cells treated with TMG for 7 days (n = 3), H2O treatment was used as a control. i mRNA levels of SOCS3 in human tTreg cells treated with TMG, H2O treatment was used as a control (n = 3). j, k Suppression activity of human tTreg cells treated with TMG for 7 days, H2O treatment was used as a control. Data are shown as mean ± s.e.m. *p < 0.05 by unpaired student’s t-test
