Fig. 8 | Nature Communications

Fig. 8

From: Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Fig. 8

Doramapimod treatment of mice is protective for peritoneal macrophages. Treatment of C57BL/6 mice with doramapimod is protective for Mtb-infected peritoneal Mφ (PM). Mice received doramapimod (100 mg/kg q.d.; i.p.) for 3 days. PM were isolated by CD11b+ selection and infected with Mtb (MOI 2 or MOI 3). Cell survival was assessed 24 h after infection by DAPI staining, using uninfected PM as a control. Control mice received the vehicle PEG 400. Data from one experiment with three mice per group and multiple replicates are shown. Results are expressed as mean ± SEM and experiments were analyzed using unpaired t-test (***p ≤ 0.001)

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