Fig. 3
From: Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
Microglia play a key role in recovery of locomotor function during the first week post-SCI. a, d, g, j Schematics of experimental design showing the timeline of microglia depletion, spinal cord contusion, behavioral testing using the Basso Mouse Scale (BMS), and sacrifice. CSF1R inhibitors and vehicle were administered in the diet or by oral gavage, as indicated. b and c, e and f, h and i, k and l Locomotor function was assessed using the BMS score (b, e, h, k) and BMS subscore (c, f, i, l) over a 35-day period after SCI (n = 8 mice per group). Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, PLX5622 versus the control group; #p < 0.05, PLX73086 versus the control group; and &p < 0.05, &&p < 0.01, &&&&p < 0.0001, PLX5622 compared to PLX73086. Statistical analysis was performed using a two-way repeated-measures ANOVA followed by a Bonferroni’s post hoc test
