Table 2 Lead SNP summary

From: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

       

CAAPA

TAGC

GWAS

Locus

Descr.

rsID

hg19 position

Genes

RA/EA

EAF

OR [95% CI]

P

EAF

OR [95% CI]

P

CAAPA

8p23

new

rs13277810

2,550,802

LOC101927815 (intronic)

C/T

0.12

1.26 [1.17-1.37]

3.2×10-8

0.19

  
 

8q24

new

rs114647118

125,531,353

TATDN1 (intronic)

C/T

0.01

0.48 [0.37-0.63]

2.7×10-7

0.00

  
 

12q13

known

rs3122929

57,509,102

STAT6, LRP1(intergenic)

C/T

0.27

1.17 [1.10-1.24]

9.1×10-7

0.34

  
 

15q22

known

rs10519067

61,068,347

RORA (intronic)

G/A

0.29

0.85 [0.80-0.90]

1.8×10-7

0.14

0.89 [0.85-0.92]

8.3x10-9

 

17q12-21

known

rs907092

37,922,259

ORMDL3,GSDMB, ZPBP2,ERBB2

G/A

0.20

0.80 [0.75-0.85]

4.3×10-12

0.47

1.08 [1.05-1.11]

3.3x10-9

TAGC

2q12

known

rs1420101

102,957,716

IL1RL1,IL1RL2, IL18R1

C/T

0.33

1.07 [1.02-1.13]

0.03

0.37

1.12 [1.10-1.15]

9.1x10-20

 

5q22.1

known

rs10455025

110,404,999

SLC25A46,TSLP

A/C

0.12

1.11 [1.01-1.22]

0.05

0.34

1.15 [1.12-1.18]

2.0x10-25

 

5q31

known

rs20541

131,995,964

IL13,RAD50,IL4

A/G

0.79

0.95 [0.89-1.02]

0.27

0.79

0.89 [0.86-0.91]

1.4x10-14

 

6p22

new

rs1233578

28,712,247

GPX5,TRIM27

A/G

0.35

1.02 [0.97-1.08]

0.32

0.13

1.11 [1.07-1.15]

5.3x10-9

 

6p21

known

rs9272346

32,604,372

HLA-DRB1, HLA-DQA1

G/A

0.56

1.07 [1.02-1.13]

0.03

0.56

1.16 [1.13-1.19]

4.8x10-28

 

9p24

known

rs992969

6,209,697

RANBP6,IL33

A/G

0.70

0.88 [0.84-0.94]

1.1x10-4

0.75

0.85 [0.82-0.88]

1.1x10-17

 

11q13

known

rs7927894

76,301,316

C11orf30,LRRC32

C/T

0.34

1.08 [1.02-1.14]

9.0x10-3

0.37

1.10 [1.07-1.13]

3.5x10-11

 

12q13

new

rs167769

57,503,775

STAT6,NAB2,LRP1

C/T

0.22

1.11 [1.04-1.19]

6.9x10-4

0.40

1.08 [1.05-1.11]

1.6x10-7

 

15q22

known

rs11071558

61,069,421

RORA,NARG2, VPS13C

A/G

   

0.14

0.89 [0.85-0.92]

1.9x10-10

 

15q22

known

rs2033784

67,449,660

SMAD3,SMAD6, AAGAB

A/G

0.42

1.04 [0.99-1.10]

0.23

0.30

1.11 [1.08-1.14]

2.5x10-14

 

17q12-21

known

rs2952156

37,876,835

ERBB2,PGAP3, C17orf37

A/G

0.58

0.92 [0.87-0.97]

0.01

0.70

0.86 [0.84-0.88]

7.6x10-29

  1. CAAPA lead SNPs (MR-MEGA association p < 10−6) and genome-wide significant associations reported by TAGC with evidence for replication in CAAPA are listed. Because some of the CAAPA studies were included in the TAGC asthma meta-analysis, and in order to contrast African and European asthma susceptibility loci, the table summarizes the associations in TAGC Europeans only (statistics from the TAGC random effects analysis, reported for the CAAPA and TAGC results). TAGC loci with strong evidence for association in CAAPA are highlighted in bold font. 1000 Genomes Project phase III European allele frequencies are reported as the estimated EAF for TAGC Europeans
  2. New asthma GWAS result not reported prior to the corresponding GWAS, Known asthma GWAS result reported prior to the corresponding GWAS. RA reference allele, EA effect allele, EAF effect allele frequency, P P asthma association
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