Fig. 8
From: Deciphering the complex role of thrombospondin-1 in glioblastoma development
Proposed model for GBM invasion TGFβ1 is expressed in both the core and the invasive areas in GBM. THBS1 is transcriptionally regulated via SMAD3, which binds to regulatory elements in the THBS1 gene. THBS1 will then be released and act on tumour cell invasion and expansion. The interaction with CD47 is critical in this process
