Table 2 Top hits from the gene-based GWA

From: Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism

Gene

Chr

Start

Stop

OPTIFAST900 (n = 1166)

DIOGENES (n = 789)

Meta-analysis

MIR486-2

8

41497961

41538025

1.7e-05 (0.043)

0.000618 (0.004)

1e-06 (1.2e-05)

MIR486

8

41497958

41538026

2.2e-05 (0.043)

0.000661 (0.004)

2e-06 (1.2e-05)

NKX6-3

8

41483828

41524878

2.4e-05 (0.043)

0.00185 (0.0074)

2.6e-05 (0.0001)

RBSG4

1

167124598

167185042

2e-05 (0.043)

0.011 (0.033)

3.8e-05 (0.00011)

DBNDD1

16

90051272

90106539

7e-06 (0.035)

0.0305 (0.073)

0.0116 (0.02)

PTPRT

20

40681391

41838557

6e-06 (0.035)

0.1728 (0.28)

0.0062 (0.012)

GAS8

16

90066036

90131379

7e-06 (0.035)

0.1958 (0.28)

0.06909 (0.1)

CCBE1

18

57078170

57384644

8e-06 (0.035)

0.2008 (0.28)

0.000346 (0.00083)

C16orf3

16

90075315

90116309

2.1e-05 (0.043)

0.2118 (0.28)

0.1049 (0.14)

URAHP

16

90086168

90134191

1.1e-05 (0.04)

0.2747 (0.33)

0.1339 (0.16)

OR5K2

3

98196524

98237475

7e-06 (0.035)

0.5784 (0.63)

0.1578 (0.17)

OR5K1

3

98168420

98209372

1.3e-05 (0.04)

0.8541 (0.85)

0.3117 (0.31)

  1. This table present gene-based association p-values for the two cohorts and their meta-analysis. False-discovery rate (FDR) adjusted p-value is indicated within parenthesis. For the discovery cohort (Optifast900), the FDR is a genome-wide FDR. For the replication cohort (DIOGENES) and the meta-analysis results, the FDR is adjusted for a two-stage analysis. FDRs less than 5% are shown in bold. Source data are provided as a Source Data file
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