Fig. 6 | Nature Communications

Fig. 6

From: PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

Fig. 6

PLCβ2-deficient mice are more susceptible to CVA16 infection. Fourteen-day-old wild-type or Plcb2−/− mice were infected intraperitoneally with 50 μl of CVA16 (1.5 × 104 PFU/mouse) for 0 or 5 days. Survival (a), clinical score (b), or histopathology of lung (c), or skeletal muscle (d) tissue of wild-type or Plcb2−/− mice (n = 6) treated as indicated. Scale bar, 50 μm. Data are representative of three experiments with at least three independent biological replicates (mean and s.e.m. of n = 6 mice per group). Gehan–Breslow–Wilcoxon test (a) and two-way analysis of variance plus Bonferroni’s posttest (b) were used to calculate p value

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