Fig. 4 | Nature Communications

Fig. 4

From: Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly

Fig. 4

FAT1 knockdown results in a failure to organize RPE cells into a monolayer. Transmission electron miscroscopy (TEM) of RPE cells cultured on trans-wells for 2 weeks following treatment with scrambled (a, c) and FAT1 shRNA (b, d). A transverse section depicting RPE cells (*, scale bar is 2 µm) sitting on top of trans-well membrane (a, arrow). A higher magnification showing epithelial tight junction (c, d, arrow, scale bar is 500 nm) between two neighboring cells

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