Fig. 2

Somatic copy number alterations of HAMPs across cancers. a The workflow of somatic copy number alteration analysis. Four criteria were used to identify the putative cancer-causing HAMPs driven by SCNAs in each cancer type. The numbers of HAMPs that passed each filter in at least one cancer type are shown on the right. b The bubble plot shows the G-scores, which consider both the amplitudes of the aberrations and the frequencies of their occurrence across samples, of the putative cancer-causing HAMPs driven by SCNAs in each cancer type. The size of the bubble: G-score; red: gain; blue: loss. The phylogenetic trees were generated by multiple sequence alignments of the full-length sequences of the proteins. c Summary of the overall G-scores of the putative cancer-causing HAMPs driven by SCNAs, which were identified in at least one cancer type. The size of the bubble: the overall G-score; red: gain; blue: loss. The HAMPs coding in black and gray indicate a gene with an overall G-score ≥ 0.8 and < 0.8, respectively. The phylogenetic trees were generated by multiple sequence alignments of the full-length sequences of the proteins