Fig. 1
From: Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
Overall structure of the NK1R–aprepitant complex. a Structure of the NK1R–aprepitant complex. The NK1R structure is shown as green cartoon. Aprepitant is shown as spheres with orange carbons. The disulfide bond is displayed as yellow sticks. The missing portion of ICL3 is indicated by a green dashed line. b, c Structural comparison between NK1R and NTSR1 (PDB accession code: 4GRV). The helical bundles of the receptors are colored green (NK1R) and purple (NTSR1). b Extracellular view. c Intracellular view
