Fig. 4
From: Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
19F NMR studies of aprepitant bound to NK1R in solution. a–j 1D 19F-NMR spectra of aprepitant in complex with different NK1R mutants and aprepitant in the DDM/CHS detergent buffer. a–e Spectral region showing the resonances of the trifluoromethyl groups of the bis-trifluoromethyl-phenylethoxy moiety; f–j Spectral region of the 4-fluorophenyl moiety. k–n, 2D [19F,19F]-EXSY spectra recorded with a mixing time of 150 ms covering the same spectral region as panels a–d
