Fig. 2

Relative stability of mutant tetramers, dimers, and monomers, with respect to WT-TTR. ΔΔG_(tetr) is the stability of the mutant tetramers with respect to WT-TTR for the process of dissociation to dimers; ΔΔG_(dime) represents the relative stability of the mutant dimers when they dissociate to monomers; ΔΔG_(mono) indicates the relative stability of the mutant monomers for unfolding; ΔΔG_(unf) is the relative stability of the mutant tetramers for the overall processes of tetramer dissociation and unfolding. The uncertainties shown are one standard error of the mean, obtained from ten repeated calculations