Table 1 Association significance between the TF binding–disrupting SNPs and gene expression in human brain tissues

From: Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk

SNP

Gene

P (CMC)

FDR (CMC)

P (LIBD)

FDR (LIBD)

P (GTEx)

rs10795

GOLGA2P7

1.63E−17

6.37E−15

1.07E−09

1.88E−07

4.50E−13 (Cau)

rs12136320

TMEM81

2.97E−05

2.00E−03

9.91E−06

7.98E−04

1.10E−06 (Putamen)

rs12912934

GOLGA2P7

2.75E−28

2.91E−25

9.30E−19

4.52E−16

1.20E−24 (Cau)

 

EFTUD1P1

4.07E−13

9.63E−11

8.48E−07

8.84E−05

1.10E−05 (Hyp)

DNM1P51

9.84E−05

4.96E−03

5.54E−10

1.02E−07

2.50E−11 (Front Cor)

rs16937

TMEM81

1.06E−05

8.06E−04

3.64E−10

6.88E−08

9.70E−07 (Putamen)

 

RBBP5

1.16E−09

1.84E−07

1.53E−04

8.56E−03

2.70E−09 (NAc)

rs1801311

NAGA

4.06E−17

1.43E−14

4.46E−29

4.42E−26

5.70E−10 (Cere)

 

FAM109B

1.46E−06

1.34E−04

6.23E−17

2.58E−14

6.30E−06 (Cortex)

rs223390

LRRC37A15P

2.58E−13

4.55E−11

1.43E−04

8.10E−03

2.30E−09 (Cere Hemi)

rs2269524

NAGA

5.33E−18

2.03E−15

1.04E−26

8.81E−24

2.90E−09 (Cere)

 

FAM109B

1.02E−06

9.73E−05

7.35E−16

2.77E−13

5.80E−06 (Cortex)

rs2270363

CORO7

2.06E−10

5.06E−08

1.72E−17

7.46E−15

8.90E−13 (ACC)

 

NMRAL1

1.62E−10

4.05E−08

4.88E−16

1.87E−13

9.00E−41 (Cere Hemi)

CDIP1

3.05E−07

4.40E−05

1.43E−05

1.11E−03

5.10E−34 (Cere)

rs2304204

CPT1C

8.51E−14

2.55E−11

4.56E−05

3.05E−03

2.00E−05 (Cere)

rs2385395

CNPPD1

4.21E−06

3.11E−04

1.10E−06

1.12E−04

4.10E−11 (Spinal cord)

rs2711116

DFNA5

5.07E−04

1.88E−02

6.63E−08

8.62E−06

2.00E−07 (Cortex)

rs281759

FTCDNL1

2.98E−13

6.79E−11

3.92E−11

8.51E−09

2.00E−06 (Hyp)

 

TYW5

2.25E−09

3.07E−07

1.80E−06

1.74E−04

5.60E−09 (Cere Hemi)

rs2856268

RLBP1

2.58E−12

5.56E−10

1.28E−08

1.89E−06

6.50E−06 (Cortex)

 

POLG

5.20E−05

2.87E−03

4.47E−06

3.93E−04

7.20E−09 (Cere)

rs2974999

TOM1L2

6.61E−14

4.75E−12

1.20E−04

6.97E−03

2.90E−06 (Cere)

rs340836

PROX1−AS1

9.71E−06

7.46E−04

3.16E−07

3.60E−05

3.30E−07 (Cere)

rs3814880

INO80E

2.28E−13

7.83E−11

7.60E−29

7.44E−26

3.30E−10 (Cere)

rs3822346

PCDHA10

1.96E−14

4.50E−12

1.30E−13

3.86E−11

1.40E−11 (Front Cor)

 

PCDHA13

3.90E−19

1.49E−16

3.21E−14

1.02E−11

4.90E−10 (Cere Hemi)

PCDHA8

2.43E−18

8.29E−16

5.03E−32

5.90E−29

3.20E−07 (Cere Hemi)

PCDHA2

3.69E−08

3.96E−06

3.96E−06

3.53E−04

6.80E−08 (Cere)

PCDHA7

9.78E−20

4.04E−17

1.30E−14

4.29E−12

5.80E−09 (Spinal cord)

rs4786494

CORO7

2.78E−10

6.71E−08

2.57E−20

1.42E−17

3.10E−13 (ACC)

rs5751195

NAGA

6.64E−19

2.71E−16

1.49E−23

1.03E−20

1.80E−21 (Cere)

 

WBP2NL

2.05E−41

4.08E−38

7.53E−12

1.81E−09

2.70E−09 (ACC)

rs6002621

FAM109B

3.09E−06

2.67E−04

3.53E−15

1.24E−12

3.40E−06 (Cortex)

 

NAGA

2.19E−17

7.87E−15

1.87E−23

1.29E−20

2.60E−09 (Cere)

rs61660810

USP32P3

5.82E−10

3.21E−08

1.40E−04

7.96E−03

2.00E−06 (Cortex)

rs6992091

FAM86B3P

5.79E−29

5.69E−26

7.93E−29

7.76E−26

7.30E−10 (Front Cor)

rs7014953

FAM86B3P

2.19E−29

2.19E−26

1.01E−26

8.58E−24

3.10E−09 (Front Cor)

rs72748702

EFTUD1P1

7.36E−14

1.95E−11

2.07E−06

1.97E−04

1.40E−05 (Hyp)

 

DNM1P51

1.33E−04

6.41E−03

5.39E−09

8.46E−07

2.20E−11 (Front Cor)

GOLGA2P7

1.40E−27

1.40E−24

2.36E−18

1.11E−15

1.90E−24(Cau)

rs778593

PCDHA10

5.19E−10

7.48E−08

1.50E−12

3.93E−10

2.40E−08 (Front Cor)

 

PCDHA13

1.06E−12

2.08E−10

2.60E−10

5.03E−08

4.00E−06 (Cere)

PCDHA8

4.71E−14

1.04E−11

6.25E−21

3.61E−18

9.10E−06 (Cere Hemi)

ZMAT2

6.87E−10

9.75E−08

1.28E−08

1.90E−06

2.40E−06 (ACC)

WDR55

1.27E−04

6.37E−03

3.83E−05

2.62E−03

1.90E−06 (Cere)

rs78532287

USP32P3

4.48E−10

2.49E−08

9.14E−13

2.46E−10

5.60E−06 (NAc)

 

CCDC144C

6.20E−17

5.16E−15

2.90E−11

6.42E−09

1.70E−06 (Putamen)

rs796364

FTCDNL1

1.01E−13

2.46E−11

9.50E−09

1.44E−06

5.80E−07 (Hyp)

 

TYW5

1.28E−08

1.54E−06

1.99E−06

1.91E−04

2.50E−08 (Cere Hemi)

rs8135801

NAGA

1.14E−17

4.22E−15

6.67E−29

6.55E−26

5.10E−09 (Cere)

 

FAM109B

6.60E−07

6.55E−05

3.84E−17

1.62E−14

6.30E−06 (Cortex)

rs9362397

C6orf162

3.16E−21

1.01E−18

4.47E−25

3.42E−22

7.70E−17 (Cere)

  1. Brain tissues from the dorsolateral prefrontal cortex (DLPFC) were used in CMC (N = 467) and LIBD brain eQTL browser (N = 412). Tissues from 8 brain regions were used in GTEx. Only SNPs that showed significant association with the expression of the same gene in all three independent expression quantitative locus (eQTL) datasets are shown
  2. TF transcription factor, SNP single-nucleotide polymorphism, CMC CommonMind Consortium, FDR false discovery rate, LIBD Lieber Institute for Brain Development, GTEx Genotype-Tissue Expression, Front Cor frontal cortex, Cau caudate, ACC anterior cingulate cortex, NAc nucleus accumbens, Cere cerebellum, Hyp hypothalamus, Cere Hemi cerebellar hemisphere, Sub nig substantia nigra, NA not available