Table 1 Association significance between the TF binding–disrupting SNPs and gene expression in human brain tissues
From: Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
SNP | Gene | P (CMC) | FDR (CMC) | P (LIBD) | FDR (LIBD) | P (GTEx) |
|---|---|---|---|---|---|---|
rs10795 | GOLGA2P7 | 1.63E−17 | 6.37E−15 | 1.07E−09 | 1.88E−07 | 4.50E−13 (Cau) |
rs12136320 | TMEM81 | 2.97E−05 | 2.00E−03 | 9.91E−06 | 7.98E−04 | 1.10E−06 (Putamen) |
rs12912934 | GOLGA2P7 | 2.75E−28 | 2.91E−25 | 9.30E−19 | 4.52E−16 | 1.20E−24 (Cau) |
EFTUD1P1 | 4.07E−13 | 9.63E−11 | 8.48E−07 | 8.84E−05 | 1.10E−05 (Hyp) | |
DNM1P51 | 9.84E−05 | 4.96E−03 | 5.54E−10 | 1.02E−07 | 2.50E−11 (Front Cor) | |
rs16937 | TMEM81 | 1.06E−05 | 8.06E−04 | 3.64E−10 | 6.88E−08 | 9.70E−07 (Putamen) |
RBBP5 | 1.16E−09 | 1.84E−07 | 1.53E−04 | 8.56E−03 | 2.70E−09 (NAc) | |
rs1801311 | NAGA | 4.06E−17 | 1.43E−14 | 4.46E−29 | 4.42E−26 | 5.70E−10 (Cere) |
FAM109B | 1.46E−06 | 1.34E−04 | 6.23E−17 | 2.58E−14 | 6.30E−06 (Cortex) | |
rs223390 | LRRC37A15P | 2.58E−13 | 4.55E−11 | 1.43E−04 | 8.10E−03 | 2.30E−09 (Cere Hemi) |
rs2269524 | NAGA | 5.33E−18 | 2.03E−15 | 1.04E−26 | 8.81E−24 | 2.90E−09 (Cere) |
FAM109B | 1.02E−06 | 9.73E−05 | 7.35E−16 | 2.77E−13 | 5.80E−06 (Cortex) | |
rs2270363 | CORO7 | 2.06E−10 | 5.06E−08 | 1.72E−17 | 7.46E−15 | 8.90E−13 (ACC) |
NMRAL1 | 1.62E−10 | 4.05E−08 | 4.88E−16 | 1.87E−13 | 9.00E−41 (Cere Hemi) | |
CDIP1 | 3.05E−07 | 4.40E−05 | 1.43E−05 | 1.11E−03 | 5.10E−34 (Cere) | |
rs2304204 | CPT1C | 8.51E−14 | 2.55E−11 | 4.56E−05 | 3.05E−03 | 2.00E−05 (Cere) |
rs2385395 | CNPPD1 | 4.21E−06 | 3.11E−04 | 1.10E−06 | 1.12E−04 | 4.10E−11 (Spinal cord) |
rs2711116 | DFNA5 | 5.07E−04 | 1.88E−02 | 6.63E−08 | 8.62E−06 | 2.00E−07 (Cortex) |
rs281759 | FTCDNL1 | 2.98E−13 | 6.79E−11 | 3.92E−11 | 8.51E−09 | 2.00E−06 (Hyp) |
TYW5 | 2.25E−09 | 3.07E−07 | 1.80E−06 | 1.74E−04 | 5.60E−09 (Cere Hemi) | |
rs2856268 | RLBP1 | 2.58E−12 | 5.56E−10 | 1.28E−08 | 1.89E−06 | 6.50E−06 (Cortex) |
POLG | 5.20E−05 | 2.87E−03 | 4.47E−06 | 3.93E−04 | 7.20E−09 (Cere) | |
rs2974999 | TOM1L2 | 6.61E−14 | 4.75E−12 | 1.20E−04 | 6.97E−03 | 2.90E−06 (Cere) |
rs340836 | PROX1−AS1 | 9.71E−06 | 7.46E−04 | 3.16E−07 | 3.60E−05 | 3.30E−07 (Cere) |
rs3814880 | INO80E | 2.28E−13 | 7.83E−11 | 7.60E−29 | 7.44E−26 | 3.30E−10 (Cere) |
rs3822346 | PCDHA10 | 1.96E−14 | 4.50E−12 | 1.30E−13 | 3.86E−11 | 1.40E−11 (Front Cor) |
PCDHA13 | 3.90E−19 | 1.49E−16 | 3.21E−14 | 1.02E−11 | 4.90E−10 (Cere Hemi) | |
PCDHA8 | 2.43E−18 | 8.29E−16 | 5.03E−32 | 5.90E−29 | 3.20E−07 (Cere Hemi) | |
PCDHA2 | 3.69E−08 | 3.96E−06 | 3.96E−06 | 3.53E−04 | 6.80E−08 (Cere) | |
PCDHA7 | 9.78E−20 | 4.04E−17 | 1.30E−14 | 4.29E−12 | 5.80E−09 (Spinal cord) | |
rs4786494 | CORO7 | 2.78E−10 | 6.71E−08 | 2.57E−20 | 1.42E−17 | 3.10E−13 (ACC) |
rs5751195 | NAGA | 6.64E−19 | 2.71E−16 | 1.49E−23 | 1.03E−20 | 1.80E−21 (Cere) |
WBP2NL | 2.05E−41 | 4.08E−38 | 7.53E−12 | 1.81E−09 | 2.70E−09 (ACC) | |
rs6002621 | FAM109B | 3.09E−06 | 2.67E−04 | 3.53E−15 | 1.24E−12 | 3.40E−06 (Cortex) |
NAGA | 2.19E−17 | 7.87E−15 | 1.87E−23 | 1.29E−20 | 2.60E−09 (Cere) | |
rs61660810 | USP32P3 | 5.82E−10 | 3.21E−08 | 1.40E−04 | 7.96E−03 | 2.00E−06 (Cortex) |
rs6992091 | FAM86B3P | 5.79E−29 | 5.69E−26 | 7.93E−29 | 7.76E−26 | 7.30E−10 (Front Cor) |
rs7014953 | FAM86B3P | 2.19E−29 | 2.19E−26 | 1.01E−26 | 8.58E−24 | 3.10E−09 (Front Cor) |
rs72748702 | EFTUD1P1 | 7.36E−14 | 1.95E−11 | 2.07E−06 | 1.97E−04 | 1.40E−05 (Hyp) |
DNM1P51 | 1.33E−04 | 6.41E−03 | 5.39E−09 | 8.46E−07 | 2.20E−11 (Front Cor) | |
GOLGA2P7 | 1.40E−27 | 1.40E−24 | 2.36E−18 | 1.11E−15 | 1.90E−24(Cau) | |
rs778593 | PCDHA10 | 5.19E−10 | 7.48E−08 | 1.50E−12 | 3.93E−10 | 2.40E−08 (Front Cor) |
PCDHA13 | 1.06E−12 | 2.08E−10 | 2.60E−10 | 5.03E−08 | 4.00E−06 (Cere) | |
PCDHA8 | 4.71E−14 | 1.04E−11 | 6.25E−21 | 3.61E−18 | 9.10E−06 (Cere Hemi) | |
ZMAT2 | 6.87E−10 | 9.75E−08 | 1.28E−08 | 1.90E−06 | 2.40E−06 (ACC) | |
WDR55 | 1.27E−04 | 6.37E−03 | 3.83E−05 | 2.62E−03 | 1.90E−06 (Cere) | |
rs78532287 | USP32P3 | 4.48E−10 | 2.49E−08 | 9.14E−13 | 2.46E−10 | 5.60E−06 (NAc) |
CCDC144C | 6.20E−17 | 5.16E−15 | 2.90E−11 | 6.42E−09 | 1.70E−06 (Putamen) | |
rs796364 | FTCDNL1 | 1.01E−13 | 2.46E−11 | 9.50E−09 | 1.44E−06 | 5.80E−07 (Hyp) |
TYW5 | 1.28E−08 | 1.54E−06 | 1.99E−06 | 1.91E−04 | 2.50E−08 (Cere Hemi) | |
rs8135801 | NAGA | 1.14E−17 | 4.22E−15 | 6.67E−29 | 6.55E−26 | 5.10E−09 (Cere) |
FAM109B | 6.60E−07 | 6.55E−05 | 3.84E−17 | 1.62E−14 | 6.30E−06 (Cortex) | |
rs9362397 | C6orf162 | 3.16E−21 | 1.01E−18 | 4.47E−25 | 3.42E−22 | 7.70E−17 (Cere) |