Fig. 7 | Nature Communications

Fig. 7

From: An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis

Fig. 7

A model of EDS1 signalling branches in RRS1S RPS4 ETI. A three-pronged ETI signalling model derives from comparisons of wild-type EDS1, EDS1R493A and eds1-2 phenotypes in this study. Three interconnected EDS1 outputs contribute to robust TNL ETI: (1) TNL-activated wild-type EDS1 effectively counters COR antagonism of immunity gene expression via MYC2. The defective EDS1 EP-domain mutant R493A is susceptible in TNL ETI against Pst AvrRps4 due to its inability to counter COR/MYC2 antagonism. (2) Wild-type EDS1 boosts SA accumulation independently of antagonising MYC2 while EDS1R493A delays SA accumulation (dashed lines) independently of COR repressive effects. (3) An additional EDS1 branch (X) in TNL (RRS1S RPS4) ETI is revealed after removing ICS1/SA and COR effects. The EDS1 EP-domain, and more specifically EDS1R493, is also required for this resistance branch. The nature of branch X requires further study

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